Nautilus Neurosciences
We are Nautilus Neurosciences, a neurology-focused specialty pharmaceutical company passionate about identifying and developing drugs that could benefit those affected by neurological disorders.

In May 2010, we launched a novel product,
CAMBIA™ (diclofenac potassium for oral solution).
Click to read important Safety Information
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About Migraines
Suffering from migraines? You’re not alone.
  • Approximately 28 million Americans suffer from migraines1,2,3
  • About 3 times as many women as men are migraine sufferers (18% and 6%, respectively)2
  • Only 48% of people with migraines reported a physician diagnosis
    of migraine, according to the American Migraine Study II1
  • Prescription medication is needed
    for treatment of moderate or severe migraines, according to the United States Headache Consortium1
Today, millions of people hope to find a better treatment for their migraines.
  • The number of visits from migraine patients seeking medical care is increasing rapidly3
  • One survey showed that more than a quarter of people with migraines were not satisfied with their treatment3*
    • Fewer than one-fifth described themselves as “very satisfied” with
      their treatment3*
What do migraine sufferers want most
from therapy?4,*
  • Complete pain relief
  • Rapid onset
  • Oral therapy
  • Treatment without side effects
*Migraine patients (n=447) who consulted family physicians in 10 Kansas practices in 2002 were assessed for patient satisfaction.
 

About CAMBIA™ (diclofenac potassium for oral solution)
 
Indication
CAMBIATM (diclofenac potassium
for oral solution) is a prescription
medicine for migraine attacks
in adults. It does not prevent or
lessen the number of migraines
you have, and it is not for other
types of headaches.

Click to read Important
Safety Information
CAMBIA is the only prescription non-steroidal anti-inflammatory drug (NSAID) available for the treatment of migraine.5

There’s no other drug quite like CAMBIA. CAMBIA is a redesigned powder form of diclofenac (dye-clo-fen-ak), one of the most commonly used NSAIDs in the world.
It provides fast relief and is easy to take.6,7 Just mix with 1 to 2 ounces of water
and drink immediately.

CAMBIA - Fast Fast
CAMBIA's powdered formulation is designed to act quickly
to provide fast pain relief.
  • In 1 pivotal study, onset of the pain-relieving effect of CAMBIA was as fast as 15 minutes7,†
  • CAMBIA can be used at any time during a migraine attack
    • In clinical studies, CAMBIA was taken by patients with moderate-to-severe headaches at the onset
      of symptoms6,7
†Compared with 60 minutes for diclofenac potassium tablets. Pivotal trial in 21 centers in 5 European countries (888 migraine attacks treated among 317 patients).
CAMBIA - Effective Effective
In clinical studies, CAMBIA has been proven to relieve the
pain and associated symptoms of migraine, including
nausea, sensitivity to light, and sensitivity to sound.6
‡FDA-mandated primary end points: pain, nausea, photophobia, and phonophobia.
 
CAMBIA - Safe Safe
All prescription drugs may cause some side effects.
  • In clinical studies of CAMBIA, the majority of adverse events were mild-to-moderate and transient6
    • The most common treatment-attributable adverse event was nausea (3% for CAMBIA vs 2%
      for placebo)8
  • See additional safety information, including boxed warning immediately below

Important Safety Information
CAMBIA is a non-steroidal anti-inflammatory drug (NSAID). NSAIDs may increase your chance of a heart attack or stroke that can lead to death. This chance is higher with longer use of NSAID medicines and in people who have heart disease. CAMBIA should never be used right before or after certain heart surgeries.

NSAID medicines can also cause stomach and intestine problems, such as ulcers and bleeding, which can happen without warning and may cause death. This risk increases with use of steroids (corticosteroids), blood thinners (anticoagulants), smoking, alcohol use, older age, and for those in poor health.


CAMBIA should be used at the lowest dose possible and for the shortest time needed.

Tell your doctor if you:
  • Are pregnant or may become pregnant, or are breast-feeding
  • Have asthma, hives, or other allergic reactions with aspirin, diclofenac, other NSAIDs, or any medicines
  • Suffer from “aspirin triad,” ie, aspirin allergy, nasal polyps, and asthma
  • Have a history of stomach ulcers or bleeding in your stomach or intestines
  • Have kidney or liver problems
  • Have chest pain, shortness of breath, irregular heartbeats, fluid retention, high blood pressure, or have a headache different from your usual migraine

Also tell your health care provider about all the medicines you take, such as prescription and nonprescription medicines, including acetaminophen, diuretics, ACE inhibitors, thiazides, antibiotics, antiepileptics, aspirin, or any anticoagulant medicines (such as warfarin, Coumadin®, or Jantoven®). Also tell your health care provider about all the vitamins and herbal supplements you take. CAMBIA and other medicines may affect each other, causing side effects or altering the way each medicine works.

Possible serious side effects of CAMBIA include heart attack, stroke, high blood pressure, heart failure from body swelling (fluid retention), kidney problems including kidney failure, bleeding and ulcers in the stomach and intestines, low red blood cells (anemia), life-threatening skin reactions, life-threatening allergic reactions, liver problems including life-threatening liver failure, and asthma attacks in people who have asthma. Common side effects of CAMBIA include nausea and dizziness.

Get emergency help right away if you have any of the following symptoms of heart attack or stroke: shortness of breath or trouble breathing, chest pain, swelling of your face or throat, weakness in one part or one side of your body, or slurred speech. Stop CAMBIA and call your health care provider right away if you experience nausea that seems out of proportion to your migraine, stomach pain, sudden or severe pain in your belly; if you vomit blood; if you have blood in your bowel movement or it is black and sticky like tar; if you experience itching, skin rashes, or blisters with fever, yellow skin or eyes, swelling of your arms and legs or hands and feet, unusual weight gain, flu-like symptoms; if you are more tired or weaker than usual; or if you have any other side effects that bother you or do not go away.

These are not all the side effects with NSAID medicines. Talk to your health care provider for more information about NSAID medicines, and consult the Medication Guide and Prescribing Information for additional information about CAMBIA’s risks.

The health information provided here is not intended to replace discussions with a health care provider. Your health care provider weighs the risks and benefits based on your individual characteristics to determine whether CAMBIA is right for you.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see Full Prescribing Information and Patient Medication Guide for additional information, including safety information.

©2011 Nautilus Neurosciences, Inc. All rights reserved

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